Worrying rise in accidental overdose of prescription drug methotrexate | smh.com.au

I’ve never understood why they make methotrexate and folic acid look nearly identical.

On vacation once, both bottles opened in my bag. I had to meticulously examine each yellow pill to sort them. Is this the little yellow pill (methotrexate) or the big yellow pill (folic acid)?

They should at least take the preventative measure of making these two very different drugs that are prescribed together different shapes and sizes.


  1. #1 by Carla Kienast on June 8, 2016 - 5:01 pm

    I’ve seen the news stories of how some patients were taking their methotrexate daily instead of weekly — which can be fatal. I have a similar issue to yours in that my diuretic looks identical to a 5 mg prednisone pill to the point that if my pill minder opens and they spill out, I have to just dump them and start over. Don’t want to take too much of either one.

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